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Ketamine Therapy

Ketamine infusion therapy may be an innovative solution for some mental health issues, particularly treatment-resistant depression. Notably, ketamine has been an FDA-approved anesthetic since the 1960s, and was used frequently on the front lines of the Vietnam War.

Since then, doctors have noticed an interesting trend among ketamine users — reduced depression levels. For example, those who respond to ketamine treatment often experience reduced suicidal ideation quickly, whereas other options usually take weeks or even months to be effective.

Importantly, ketamine is not FDA-approved to treat mental health conditions. However, practitioners successfully use “off-label” (generic) ketamine during therapy sessions to help patients overcome chronic depression. In fact, researchers suggest that ketamine, when administered slowly through an IV, exerts a calming effect on the parts of the brain that control mood and behavior.

What is Ketamine?

Ketamine is a white or light brown powder on the streets and a clear liquid in a medical setting. Common methods of ingestion include snorting or eating it (when consumed recreationally) or through an IV in a clinic. Consumers may feel the effects immediately or up to 30 minutes after consumption depending on the mode of ingestion, and will usually feel its effects for about an hour.

The most common sensations associated with ketamine use include feelings of bliss, confusion, detachment, relaxation, and being “tripped out.” Higher doses of ketamine may also cause nausea, depression, memory loss, and painlessness.

Is Ketamine Therapeutic?

Intravenous ketamine includes two mirror molecules: R-ketamine and S-ketamine. Together, these molecules help reduce pain and induce antidepressant activity.

Though we don’t fully understand why ketamine exerts these therapeutic qualities, experts believe it’s because of the way it binds to NMDA receptors in the brain, which increases glutamate production. Notably, this neurotransmitter activates AMPA receptors. When AMPA and NMDA fire in unison, the brain releases additional molecules that aid neural communication along new pathways. This process called synaptogenesis directly affects mood, cognition, and thought patterns.

However, synaptic development is only one method by which psychedelics like ketamine may help improve mood. Further research suggests that ketamine reduces brain inflammation by dulling the signals that trigger it. These three mechanisms (reducing brain inflammation, facilitating cellular communication, and promoting the development of new neurological pathways) may help explain ketamine’s therapeutic potential for treating mood disorders.

What to Expect from Ketamine Infusion Therapy

Those with treatment resistant depression may find relief with ketamine infusion therapy. A medical practitioner will help determine if ketamine therapy is a viable option, which generally only happens as a last line of defense.

Notably, ketamine therapy is most effective when administered slowly through an IV as clinicians monitor the patient. To ensure the best possible experience, clinicians will set up the patient in a private, comfortable room, which may include calming lighting and music, as well.

Aside from the initial prick of the IV needle, the experience is completely painless. Patients usually feel a boost in spirits almost immediately, but will not feel an intense “high” that often accompanies opioid medications. Patients may also feed slightly sedated, but usually remain awake for the whole treatment.

Ketamine therapy is usually effective after the first treatment with results lasting up to two weeks on average. However, long-term care often requires follow-up infusions, which may include a series of up to six more infusions over a two- to three-week period.

After this “induction” phase of ketamine therapy, the patient and doctor will decide together what to do next. For example, they may cease ketamine treatment at this time or begin a “maintenance” period, instead. Ketamine maintenance involves additional infusions every two to six weeks to help the patient sustain initial positive results of ketamine infusion therapy.

Notably, it’s not always realistic to expect patients to return for IV therapy indefinitely. As such, nasal ketamine medications may offer comparable benefit. However, nasal ketamine medicines only include S-ketamine, which may not be as effective as racemic ketamine, or ketamine that includes both S- and R-ketamine.

Where to find Ketamine Therapy Near you

30 US states currently offer ketamine infusion therapy, plus some locations in Spain and Canada. Below is a list of current ketamine infusion therapy centers. Please check back often for updates.

Ketamine Infusion Therapy Centers

Allay Health and Wellness


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AMG Ketamine and Wellness Center


APS Ketamine


Avesta Ketamine and Wellness


avIVa Infusions


Balance Ketamine Clinics

1601 W. Division St., Ste. A Chicago, IL 60622

Provider: Abhijit Shinde, MD, PhD

MDPhDInternal Medicine

Balanced Mental Wellness

This Colorado ketamine infusion clinic offers treatments such as Ketamine Assisted Psychotherapy, Integrative Psychiatry, and Better Together Healing.

Bay Area Ketamine Center

Bay Area Ketamine Center offers ketamine infusion treatments for depression, chronic pain, anxiety, OCD, PTSD, and more out of California.

Boston Infusion Center


Canadian Rapid Treatment Center of Excellence


Care Clinic




Cedar Psychiatry


Center for Holistic Healthcare

Center for Holistic Healthcare offers ketamine therapy for treatment of pain and mood disorders.

CIT Clinics

CIT Clinics offer ketamine infusion therapy for treatment of depression, anxiety, PTSD, migraines CRPS, chronic pain, immunity and resilience, athletic performance and more out of California.

Cleveland Medical Institute


Defy Medical


DENT Ketamine Clinic

New York

Desert Ketamine Clinic


Dr. Ditzell Psychiatry

New York

Elev8MD Wellness Center

North Carolina

Field Trip Health

New York

Genesys Infusion Center


Happier You Ketamine Clinic


Harbour Towne Health


Help Specialist


Indy Advanced Therapeutics


Innovative Ketamine


Integrative Pain Management


IV Solution and Ketamine Centers of Chicago




Jackson Hole Ketamine Clinic


Kalypso Wellness Center


Kentuckiana Integrative Medicine


Ketamine Clinic of Hawaii


Ketamine Clinics of Los Angeles


Ketamine For Wellness


Ketamine Health and Wellness

New Jersey

Ketamine Health Centers


Klarity Clinic


Klarity Ketamine Clinic


Klarity Ketamine Clinic of Southern California

Klarity Ketamine Clinic of Southern California offers ketamine infusion therapy and claims to have a greater than 85% success rate for depression, PTSD, and higher success rates with drug and alcohol patients.

Lenox Hill Mind Care

New York

Lighthouse Infusions and Seattle Ketamine


Lighthouse Wellness Spa

Lighthouse Wellness Spa offers ketamine infusion therapy for Chronic Pain, Migraines, Anxiety, Depression, and PTSD.

MD Infusions


Measured Wellness


Mind and Body Infusion Therapies


Miracle Hills Clinic


Morpheus IV Hyrdration and Infusion Clinic


New England Ketamine

New Hampshire

New Life Ketamine


New Pathways Clinic


North Branch Health


North Jersey Interventional Pain and Ketamine Center

New Jersey

NOVA Health Recovery Ketamine Infusion Center


NY Ketamine Infusions

New York

Pain Medicine Consultants


Pain Medicine Consultants

Pain Medicine Consultants use ketamine infusion therapy as a treatment option for chronic pain, anxiety, depression, and stress. Their treatment team consist of Harvard-, Stanford-, and Mayo Clinic-trained doctors out of California.

Palomar KLN Infusion Center

Palomar KLN Infusion Center offers an array of alternative medicine services including ketamine lidocaine and iv nutrition infusion therapy.

PalomarKLN Infusion Center


Prestige Infusions

New Jersey

Priority You

Priority You offers patients a unique trifecta of alternative, wellness and regenerative health center that specializes in ketamine therapy.

Recharge Clinic


Restoration Infusions Clinic


Revive Ketamine Clinic


Satori Health and Wellness


Scenic City Neurotherapy and Ketamine Center


Soft Reboot Wellness

Soft Reboot Wellness offers IV ketamine therapy and determines dose based on the individual patient and not weight recommendations.

Southwest Pain Center

New Mexico

Spark Psychedelic Therapy

Spark Psychedelic Therapy offers concierge ketamine infusions and Telehealth integration and therapy.

Specialized Infusions


Springview Ketamine Behavioral Services


Summit Ketamine Innovations

Summit Ketamine Innovations is treating patients with ketamine IV therapy for conditions such as Depression, Postpartum, Anxiety, PTSD, OCD, Bipolar, Suicidal Ideation Treatment, Chronic Pain, CRPS, Migraine, Fibromyalgia, Neuropathy, RLS and more.

The Florida Psychiatric Center

The Florida Psychiatric Center provides ketamine therapy options to patients treating both depression and anxiety.

The Linden Medical Centre


TMS & Brain Health

TMS & Brain Health TMS therapy, ketamine treatment, and neurofeedback to help treatment at this practice out of California

Tristar Wellness


University of Utah Health Care


Ventura Center for Advanced Therapeutics


Ventura Center for Advanced Therapeutics

Ventura Center for Advanced Therapeutics offers ketamine infusion therapy to treat various chronic pain, chronic migraines, fibromyalgia, and peripheral neuropathy in addition to treatment-resistant depression, PTSD and other mental health conditions out of California.

Vitalis Denver Ketamine Centers

With multiple Denver Metro Area clinics, Vitalis Denver Ketamine Centers offers ketamine infusion therapy to treat  TRD, postpartum depression, bipolar disorder, anxiety and PTSD and more.

Wholistic Wealth


Wyoming Wellness Center


Final Thoughts About Ketamine Infusion Therapy

Ketamine is just one of many psychedelic substances that clinicians use to promote better mental health. Breakthroughs in psychedelic research have proven its therapeutic potential, allowing patients to finally receive help for their treatment-resistant depression.